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Puffs tissues are on sale for $0.99 at Walgreens. Use a $0.25 coupon with a $1.00 Checkout 51 rebate to make $0.26 on a box of Puffs! Rebates vary by user, so you might have a $0.75 offer instead. Either rebate will make these tissues a moneymaker.
Update: The Checkout 51 Puffs offer has run out, so the deal is no longer available.